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Dr. John Chik's interest in questions that lie at the intersection of biology, chemistry and physics was planted when, as a graduate student, he became fascinated by the mystery of how living organisms exploit ATP (adenosine triphosphate) hydrolysis to generate mechanical work, as exemplified by muscle contraction. Through an adjunct-assistant professorship at the University of Calgary, he is continuing muscle-related research by co-supervising a MSc student project using the novel method of hydrogen/deuterium exchange mass spectrometry to study calmodulin-mediated, calcium activation of smooth muscle contraction, and an undergraduate summer student project examining the mechanism behind smooth muscle myosin activation by light-chain phosphorylation. Funded by MRU, Dr. Chik has also initiated research exploiting the novel properties of "heavy water" to investigate "water-mediated" force, such as the hydrophobicity and hydration forces, and how they influence protein structure and function. In addition to furthering our understanding of the life-critical properties of water, this research will have practical implications for improving protein stability which, for example, would be of interest in the area of vaccine storage.
- The effects of Heavy Water on Protein/Protein and Protein/DNA Interactions
- Assessing the feasibility of equilibrium labeling method in hydrogen/deuterium exchange mass spectrometry
Ph.D. in Chemistry, 1989 - 1996. Princeton University. Specialization: Protien Crystallography. Dissertation title: "Solid State Transformations of Crystalline Bovine Profilin Beta-Actin Complex at Atomic Resolution". Supervised by: Schutt, C.E.
B.Sc. (With Distinction) in Chemical Physics, 1985 - 1989. University of Toronto.
MacDonald, J.A., Ulke-Lemee, A., Butler, E.I., Ishida, H., Chappellaz, M., Chik, J.K., & Vogel, H.J. (2012, April 3). The intrinsically disordered N-terminus of calponin homology-associated smooth muscle protein (CHASM) interacts with the calponin homology domain to enable tropomyosin binding. Biochemistry, 51(13), 2694-2705.
Chik, J.K. (2012). In. (R. Bissessur, G.R. Loppnow, N.J. Mosey, J. Carran, & J.K. Chik, Eds.), Chemistry, Student Activity, Chemical Reactivity (pp.443-456). Scarborough: Nelson. (Status: In Print).
Chik, J.K., Schriemer, D.C., Childs, S.J., & McGhee, J.D. (2011). Proteome of the Caenorhabditis elegans Oocyte. Journal of Proteome Research, 10(2300), 2305.
Bennet, M., Chik, J.K., Slysz, G.W., Luchko, T., Tuszynski, J., Sackett, D.L., & Schriemer, D.C. (2009). Structural mass spectrometry of the αβ-tubulin dimer supports a revised model of microtubule assembly. Biochemistry, 48, 4858-4870.
Huzil, J.T., Chik, J.K., Slysz, G.W., Freedman, H., Tuszynski, J., Taylor, R.E., Sackett, D.L., & Schriemer, D.C. (2008). Discovery of the peloruside binding site on microtubules and a unique mechanism of microtubule stabilization. Journal of Molecular Biology, 378, 1016-1030 (In Print).
Chik, J.K., Vande Graaf, J.L., & Schriemer, D.C. (2006). Quantitating the statistical distribution of deuterium incorporation extends the utility of H/D exchange MS data. Analytical Chemistry, 78, 207-214 (In Print).
Chik, J.K., Mizrahi, S., Chi, S., Parsegian, V.A., & Rau, D.C. (2005). Hydration forces underlie the exclusion of salts and neutral polar solutes from hydroxypropylcellulose. Journal of Physical Chemistry B, 109, 9111-9118 (In Print).
Lovelace, J., Narayan, K., Chik, J.K., Bellamy, H.D., Snell, E.H., Lindberg, U., Schutt, C.E., & Borgstahl, G.E.O. (2004). Three dimensional imaging of reflections from a modulated semi-crystalline state of profilin:actin. Journal of Applied Crystallography, 37, 327-330 (In Print).
Chik, J.K., & Schriemer, D.C. (2003). Hydrogen/deuterium exchange mass spectrometry of actin in various biochemical contexts. Journal of Molecular Biology, 334, 373-385 (In Print).
Cheng, Y., Prud'homme, R.K., Chik, J.K., & Rau, D.C. (2002). Measurement of forces between galactomannan polymer chains: Effect of hydrogen bonding. Macromolecules, 35, 10155-10161 (In Print).
Chik, J.K., & Parsegian, V.A. (2001). The entropically favored osmotic 'compression' of sickle cell hemoglobin gels. Biopolymers, 59, 120-124 (In Print).
Chik, J.K., Lindberg, U., & Schutt, C.E. (1996). An open-state of bovine profilin:ß-actin at 2.65Å resolution. Journal of Molecular Biology, 263, 607-623 (In Print).
Educational Institution Employment
Assistant Professor, Chemical and Biological Sciences, Mount Royal University, Canada, 2009 - Present (Full Time).
Adjunct Assistant Professor, Biochemistry and Molecular Biology, University of Calgary, 2008 - Present (Adjunct).
Research Assistant, Biochemistry and Molecular Biology, University of Calgary (Calgary, AB Campus), Canada, 2001 - 2008 (Full Time).
Post-Doctoral Fellow, National Institute of Child Health and Development, National Institutes of Health (Bethesda, MD Campus), United States, 1996 - 2001 (Full Time).
2011, January - 2011, May BCEM3202 "Enzymes and Metabolic Systems". Level: Undergraduate Y3. Students: 16. Credits: 3. Hours: Lecture: 3 Other Contact: 2.
2010 - 2011 BCEM2201 "General Biochemistry". Level: Undergraduate Y2. Students: 36. Credits: 3. Hours: Lecture: 3 Other Contact: 2.
2010, January - 2010, May CHEM2210 "Behaviour of LIquids, Gases and Solids". Level: Undergraduate Y1. Hours: Tutorial: 3.
2009 - 2010 GNED1102 "Controversies in Science". Level: Undergraduate Y1. Hours: Lecture: 3.
2009, September - 2009, December CHEM2209 "General Chem. for Engineers". Level: Undergraduate Y1. Hours: Tutorial: 3.
2008 - 2009 PHYS223 "Introduction to Electromagnetism and Thermal Physics" at University of Calgary, Dept of Physics. Level: Undergraduate Y1. Students: 160. Credits: 3. Hours: Lecture: 3 Other Contact: 2.
(2011, January). BCEM 3202 Coordinator, Chemical and Biological Sciences.
(2010, September). BCEM 2201 Coordinator, Chemical and Biological Sciences.
2011, April MRU: Internal Research Grant, "The effects of Heavy Water on Protein/Protein and Protein/DNA Interactions". CAD4,000. Type: Grant-Competitive (Role: Principal Investigator).
2010 - 2011 Mount Royal University: Research Reserve, "The effects of Heavy Water on Protein/Protein and Protein/DNA Interactions". $4,000 (Role: Principal Investigator).
2011, June 9. "Just when I thought I was out (of actin)". Presented at Schutt Festschrift - A Structural Biology Symposium, Princeton, NJ. Invited Speaker.
Choi, M.L., Walsh, M., & Chik, J.K. (2010). Investigating Novel Molecular Events Involved in Calcium-Calmodulin Activation of Smooth Muscle Myosin Light Chain Kinase Using Hydrogen-Deuterium Exchange Mass Spectrometry. Presented at Annual Meeting of the American Mass Spectrometry Society (Salt Lake City, Utah).
Yang, A., & Chik, J.K. (2010). The potential for synergistic protein digestion using multiple, immobilized protease for hydrogen/deuterium exchange mass spectrometry. Presented at Annual Meeting of the American Mass Spectrometry Society (Salt Lake City, Utah). (Role: Presenter).